Risk factors associated with prolonged Nasopharyngeal carriage of SARS-CoV-2 and length of stay among patients admitted to a COVID-19 referral center in Manila, Philippines
https://doi.org/10.47895/amp.vi0.5764
- Author:
Ma. Sergia Fatima P. Sucaldito
1
;
Bea Regine C. Panganiban
1
;
Cecilia A. Jimeno
1
Author Information
1. Philippine General Hospital, University of the Philippines Manila
- Publication Type:Journal Article
- Keywords:
Nasopharyngeal carriage
- MeSH:
COVID-19;
Length of Stay
- From:
Acta Medica Philippina
2020;54(Online):1-7
- CountryPhilippines
- Language:English
-
Abstract:
Objective:Prolonged nasopharyngeal carriage of SARS-CoV-2 has been linked to prolonged hospital stay and delayed radiologic recovery. To determine if clinical risk factors are associated with prolonged nasopharyngeal carriage or longer hospital stay, we performed a descriptive analysis of 169 moderate to severe COVID-19 patients admitted at the Philippine General Hospital from March to June 2020.
Methods:Length of nasopharyngeal RT-PCR positivity and clinical demographic data were extracted from existing patient records. Chi-square test, Mann-Whitney U test, and regression analysis were performed to describe the association of clinical risk factors with prolonged nasopharyngeal carriage and length of hospital stay.
Results:The median duration of carriage was 19 days (IQR 12.0-30.0 days). No comorbidities or inflammatory
markers had a statistically significant association with prolonged nasopharyngeal carriage defined as >24 days of nasopharyngeal RT-PCR positivity. Characteristics associated with a statistically significant longer hospital stay included chronic kidney disease stages 3-5, severe disease, and use of empiric antibiotics on admission. Prolonged carriage >24 days, hsCRP, and D-dimer at admission, also had a statistically significant but weak correlation with length of stay.
Conclusion:Among patients with moderate disease, comorbidities and inflammatory markers were not associated with prolonged COVID-19 nasopharyngeal carriage. Prolonged nasopharyngeal carriage >24 days was associated with longer hospital stay, while D-dimer and hsCRP levels at admission, also had statistically significant but small effects on increasing the hospital length of stay
- Full text:5764-Article Text-78775-1-10-20220907.pdf
