Genetic Analysis of a Young Adult Presented with Acute  Myocardial Infarction with No Traditional Risk Factors: A Novel  Case Report

Huzairi Sani; Lay Kek Teh; Mohd Nur Fakhruzzaman Noorizhab; Mohd Zaki Salleh; Sazzli Shahlan Kasim

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Genetic Analysis of a Young Adult Presented with Acute Myocardial Infarction with No Traditional Risk Factors: A Novel Case Report

Author: Huzairi Sani ^{1
,

2
,

3} ; Lay Kek Teh ² ; Mohd Nur Fakhruzzaman Noorizhab ² ; Mohd Zaki Salleh ² ; Sazzli Shahlan Kasim ^{1
,

3
,

4}
Author Information

1. Cardiology unit, Internal Medicine department, Faculty of Medicine, Universiti Teknologi MARA Sungai Buloh 47000, Selangor, Malaysia&
2. Integrative Pharmacogenomics Institute (iPROMISE),UiTM Puncak Alam Campus, Bandar Puncak Alam, 42300 Puncak Alam, Selangor, Malaysia&
3. Cardiac Vascular and Lung Research Institute, Universiti Teknologi MARA (UiTM), Malaysia&
4. Institute of Pathology, Laboratory and Forensic Medicine (I-PPerForM), Aras 4, Bangunan Akademik, UiTM Kampus Sungai Buloh, 47000 Jalan Hospital, Sungai Buloh, Selangor, Malaysia
Publication Type:Case Reports
Keywords: Young onset myocardial infarction, ST-elevation, Infinium Asian Screening Array, Preventive and personalised medicine
From:Malaysian Journal of Medicine and Health Sciences 2022;18(No.1):349-352
CountryMalaysia
Language:English
Abstract: Myocardial infarction (MI) in the young adults are more common among the Asians compared to the Caucasians. It is of great interest to investigate the genetic risks that increase the susceptibility of MI in young patients with no family history. We conducted a genetic analysis on a young adult diagnosed with acute MI. The coronary angiogram showed acute complete occlusion of the left anterior descending artery with 40% left ventricular ejection fraction (LVEF). Patient’s DNA was subjected to genotyping using Infinium Asian Screening Array. The genotypes were annotated and associated with risks of cardiovascular diseases catalogued in GWAS database. Ninety-four genetic variants were detected. Patient has more than half of the genetic variants being homozygous risk genotypes for coronary artery and coronary heart diseases. Identifying the potential genetic modifiers associated with MI in young patients is of great interest to help the clinician make informed decisions to implement preventive and personalised medicine for this patient.
Full text:11.2022my1220.pdf