Assessment of renal function in chronic hepatitis C patients
- VernacularTitle:С вирусийн шалтгаант архаг хепатиттай өвчтөнд бөөрний үйл ажиллагааны алдагдлыг илрүүлэх нь
- Author:
Gantogtokh D
1
,
2
;
Batsukh B
3
;
Batbold B
1
;
Burmaajav B
2
Author Information
1. Institute of Medical Sciences
2. Ach Medical University
3. National Center for Communicable Diseases
- Publication Type:Journal Article
- Keywords:
hepatitis C virus infection;
chronic kidney disease;
glomerular filtration rate;
liver cirrohis;
clinical relevance
- From:Mongolian Medical Sciences
2023;204(2):3-13
- CountryMongolia
- Language:Mongolian
-
Abstract:
Background:The association between hepatitis C virus (HCV) infection and chronic kidney disease (CKD) still
remains controversial. We aimed to investigate whether HCV really affects renal function, and to
analyze the association between clinical effects of CHC and decreased kidney function (assessed by
glomerular filtration rate (eGFR) level).
Aim:Study of renal dysfunction in chronic hepatitis C virus infection
Materials and Methods:An estimated 222 patients with HCV infection and 222 age- and sex-matched community-based
control individuals without HCV were enrolled (1:1, case and control ratio) in this study between from
June 2022 to March 2023. We used the modification of diet in renal diseases to calculate eGFR.
This study was approved by the review board of the Ethics Subcommittee of Ach Medical University
and followed the Declaration of Helsinki. All statistical analysis was performed with SPSS version
26.0 software (SPSS Inc., Chicago, IL, USA), and a P value < 0.05 was considered statistically
significant. Continuous variebles were presented as mean ± standard deviation, while categorical
data was represented as numbers and percentages. Independent t-tests were used to compare the
differences in parametric variables. The Mann-Whitney U test was performed to compare the follow-up
period. Pearson’s chi-squared and Fisher’s exact tests were used to compare categorical variables.
Multivariate logistic regression was used to identify the risk factors associated with recurrence.
Results:The median age of the respondents was 40 (range 21-70). In the case group, the speed of hanging
judgment was 105.3±24.5, and in the control group, it was 118.7±18.5, which was a statistically
significant difference (p<0.05, p<0.05). It was observed that the rate of filtration of the renal is below
90 or the loss of renal function increases with age (47.50±9.3 vs 40.21±11.1; p<0.01). In order to
reduce the effect of age, when evaluating the renal function of participants over 45 years of age
in the case-control group, the HCV was 99.69 in the case group and 111.05 in the control group,
although there was an age effect on the decline in HCV in both groups, but it decreased more in the
HCV-infected group. When comparing two groups (<3.25, >3.25) with liver fibrosis degree above
and below 3.25, the higher degree of fibrosis affects the decrease in the rate of hepatic filtration (112.92±19.8 vs 105.23±27.1; p<0.01). The proportion of cryoglobulinemia was high when renal
dysfunction was beginning or when the GFR was below 90 (<90). Logistic regression analysis showed
that cryoglobulinemia had the greatest influence on the decrease in glomerular filtration rate (OR
4.22, 95% CI 1.97-9.00, p<0.05). The relationship between age and the decline in hanging judgment
speed was statistically significant and directly moderate (r=0.95, p=0.009). On the other hand, there
is a statistical relationship between gender and the decrease in the speed of hanging judgment, with
a probable and weak correlation (r=0.07, p=0.01).
Conclusion:Our study found that the patients with HCV infection are associated with a low
eGFR compared with non-HCV–infected patients. This association is consistent in age, gender,
cryoglobulinemia and liver fibrosis patients.
- Full text:2023-204(2)-3-13.pdf
