Advances in the establishment of rodent model of alcoholic liver disease
- Author:
WU Mu-qing
;
LI Ang
;
FU Juan
;
LI Guang-hai
;
LI Jin-qian
;
WU Tao
- Publication Type:Review
- Keywords:
Alcoholic liver disease;
liver fibrosis;
liver cirrhosis;
animal models
- From:
China Tropical Medicine
2022;22(10):984-
- CountryChina
- Language:Chinese
-
Abstract:
Abstract:Alcoholic liver disease (ALD) is one of the most common liver diseases in the world. Long-term alcoholism causes a series of pathological changes in the liver, which eventually leads to the occurrence of liver diseases with an increasing incidence. At present, significant progress has been made in the pathogenesis and pathological development of alcoholic liver disease, but the relevant mechanism of ALD has not been thoroughly studied. It is necessary to improve the existing animal model or establish a new, more comprehensive animal ALD model to simulate human ALD. Experimental animal models of ALD, especially rodents, are often used to simulate human ALD, and the ideal rodent ALD model can effectively simulate all aspects of alcohol in human liver. But so far, the commonly used animal models all have certain defects, and there is no complete animal model that can simulate human ALD. This paper reviewed the pathogenesis of ALD, related methods and influencing factors of ALD model, and provided a theoretical basis for relevant researchers to establish the ALD rodent model.
- Full text:18.Advances in the establishment of rodent model of alcoholic liver disease.pdf
