Optimization of the extraction process for Xuelian yishen formula by the combination of entropy weight method-analytic hierarchy process with Box-Behnken response surface methodology
- VernacularTitle:熵权法-层次分析法结合Box-Behnken响应面法优化雪莲益肾方的提取工艺
- Author:
Taximaimaiti XIATIGULI
1
,
2
;
Yuan ZHAO
3
;
Yi LIU
3
;
Deqiang DENG
3
;
Aisa HAJI-AKBER
1
;
Tao WU
1
Author Information
1. Key Laboratory of Plant Resources and Chemistry in Arid Regions，Xinjiang Technical Institute of Physics and Chemistry，Chinese Academy of Sciences，Urumqi 830011，China
2. School of Chemistry，University of Chinese Academy of Sciences，Beijing 100049，China
3. Dept. of Pharmacy，Urumqi Hospital of Traditional Chinese Medicine，Urumqi 830011，China
- Publication Type:Journal Article
- Keywords:
Xuelian yishen formula;
entropy weight method;
analytic hierarchy process method;
Box-Behnken response
- From:
China Pharmacy
2023;34(15):1858-1862
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To optimize the extraction process of Xuelian yishen formula. METHODS The contents of total flavone， echinacoside and acteoside， and extraction yield in Xuelian yishen formula were chosen as indexes， entropy weight method-analytic hierarchy process was adopted to determine the weight coefficient. Box-Behnken response surface methodology was used to optimize the extraction process of Xuelian yishen formula with extraction time， solid-liquid ratio and extraction times as factors， using comprehensive score of above indexes as index. RESULTS The optimal extraction process of Xuelian yishen formula was extraction time of 2 h， solid-liquid ratio of 1∶12， extracting for 3 times. Average comprehensive score of 3 validation tests was 96.40 points （RSD＝0.28%）， the deviation of which with predictive value was 0.98%. CONCLUSIONS The optimized extraction process is stable， feasible and reproducible， which can provide reference for the extraction process of Xuelian yishen formula.
