Early protective effects of transplantation of fetal spinal cord and bFGF on spinal cord injury in adult rats
- VernacularTitle:胚胎脊髓移植联合应用bFGF对脊髓神经组织损伤的早期保护作用
- Author:
Fengjin GUO
;
Xinzhi LI
;
Tao XU
;
Anmin CHEN
- Publication Type:Journal Article
- Keywords:
fetal spinal cord cell, basic fibroblast growth factor, spinal cord injury
- From:
Chinese Journal of Rehabilitation Theory and Practice
2005;11(12):968-970
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo explore the early effects of transplantation of fetal spinal cord (FSC) and basic fibroblast growth factor (bFGF) on calcium, magnesium of injured spinal cord.MethodsThe spinal cord injury (SCI) animal model was established with Wistar rats. The rats were divided into 3 groups. The group A was received FSC cells suspension 5 ml after injury. The group B was received FSC cells suspension and bFGF 20 μl. The group C was not treated with any therapy. The values of Ca2+, Mg2+ of injured spinal cord tissues were measured at 6, 24 hours after injury. The morphyological results were observed by electron microscope on the fifth day.ResultsThe degree of ionic disorder in FSC+bFGF treated rats was strikingly ameliorated and the contents of H2O also decreased. The morphyological finding revealed that in FSC+bFGF treated rats, the damage of gray and white matters was slight in contrast to those of control group rats, which appeared a typically damage.ConclusionTransplantation of FSC and bFGF has some protective effects on contused spinal cord in rats.
