Effect of hyperbric oxygen on infarct volume and matrix metalloproteinase after permanent focal cerebral ischemia in adult rats
- VernacularTitle:高压氧对成年大鼠脑梗死灶体积和基质金属蛋白酶的影响
- Author:
Yu PAN
;
Chao-dong ZHANG
- Publication Type:Journal Article
- Keywords:
hyperbric oxygen (HBO), focal cerebral ischemia, matrix metalloproteinase (MMP)
- From:
Chinese Journal of Rehabilitation Theory and Practice
2004;10(12):726-728
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the effect of hyperbric oxygen (HBO) on infarct volume and relevant mechanism after permanent focal cerebral ischemia in adult rats.MethodsRat model of focal cerebral ischemia induced by intraluminal filament occlusion of middle cerebral artery (MCA) was used. HBO(2.0 ATA) was applied to HBO group. Infarct volume, matrix metalloproteinase 2 (MMP-2) and MMP-9 were detected at 6h, 24h, 48h, 72h,120h and 10d after ischemia.ResultsThe infarct volume obviously decreased at 120h and 10d and expression of MMP-9 lowered at 48—120h in HBO groups. There was no significant change in MMP-2.Conclusion HBO can reduce infarct volume after cerebral ischemia, which may be related to downregulation of MMP-9 levels.
