Progress in the research of COVID-19 effects on Alzheimer's disease
- Author:
WANG Jin-pei
;
JIANG Qi
;
LI Gui-li
;
WU Jia
;
ZHAO Jin-rong
- Publication Type:Review
- Keywords:
COVID-19;
SARS-CoV-2;
Alzheimer's disease
- From:
China Tropical Medicine
2023;23(3):304-
- CountryChina
- Language:Chinese
-
Abstract:
Coronavirus disease 2019 (COVID-19) is a highly contagious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). More than one-third of patients with COVID-19 experience neurological symptoms, including confusion, headaches, and decreased/disordered taste. Alzheimer's disease (AD) is a slowly progressive neurodegenerative disease and the most common type of dementia. Alzheimer's disease patients are at high risk and susceptible to infection with COVID-19, which may cause severe illness and even death. There appears to be an interaction between AD and COVID-19, and on the one hand, patients with COVID-19 seem to be more likely to develop AD. AD patients, on the other hand, may be more susceptible to severe COVID-19. Therefore, understanding the common link between COVID-19 and AD may help to develop treatment strategies. Risk factors common to AD and COVID-19 are aging, ApoE ε4 allele, β-amyloid (Aβ) deposition, angiotensin-converting enzyme (ACE), neuroinflammation, oxidative stress. Here, this article focuses on the relationship between COVID-19 and AD, explores common risk factors and potential pathogenesis, and provides help for early prevention, treatment and recovery.
- Full text:17.Progress in the research of COVID-19 effects on Alzheimer's disease.pdf
