Urinalysis of transforming growth factor-β1 in old patients with diabetic nephropathy
- VernacularTitle:尿转化生长因子β1对老年人早期糖尿病肾病的诊断意义
- Author:
Jianjian YAO
;
Yunjuan QIAN
;
Qi LIN
;
Dongfeng LI
- Publication Type:Journal Article
- Keywords:
diabetes mellitus, complication, diabetic nephropathy, transforming growth factor-β1
- From:
Chinese Journal of Rehabilitation Theory and Practice
2005;11(11):940-941
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo search detecting urine transforming growth factor-β1(TGF-β1) of type 2 diabetes mellitus(DM) in diagnosing early diabetic nephropathy in old patients.MethodsTGF-β1,microalbumin,microglobulin α1 and microglobulin β2 in urine from 53 cases of old type 2 diabetics and 27 cases of normal controls were detected.ResultsTGF-β1 was(21.2±7.32) ng/mmolCr in diabetics whose urine albumin were normal and was(58.79±25.93) ng/mmolCr in diabetics whose urine microalbumin was abnormal(P<0.01).Both were significantly higher than that of the normal control which was(7.79±3.58) ng/mmolCr(P<0.01).TGF-β1 was direct remarkably correlative with microablumin(r=0.5415),microglobulin α1(r=0.6282) and microglobulin β2(r=0.3248)(P<0.01 respectively),but was nothing with glycohemoglobin(r=0.2304,P>0.05).ConclusionTGF-β1 detection may be used as a sensitive and reliable guideline to diagnose early diabetic nephropathy in old diabetics.
