Prognostic value of the preoperative systemic immune-inflammation index in patients with non-small cell lung cancer: A systematic review and meta-analysis
- VernacularTitle:术前系统免疫炎症指数对非小细胞肺癌患者预后价值的系统评价与Meta分析
- Author:
Mengqi CHEN
1
,
2
;
Kemeng LIU
3
,
4
;
Huaqin ZHAO
1
,
2
;
Xia HE
1
,
2
Author Information
1. Department of Respiratory and Critical Care Medicine, Second People'
2. s Hospital of Deyang City, Deyang, 618000, Sichuan, P. R. China
3. Department of Thoracic Surgery, Renshou County People'
4. s Hospital, Meishan, 620500, Sichuan, P. R. China
- Publication Type:Journal Article
- Keywords:
Systemic immune-inflammation index;
non-small cell lung cancer;
prognosis;
systematic review/meta-analysis
- From:
Chinese Journal of Clinical Thoracic and Cardiovascular Surgery
2023;30(03):440-446
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the association between the preoperative systemic immune-inflammation index (SII) and prognosis in non-small cell lung cancer (NSCLC) patients. Methods A comprehensive literature survey was performed on PubMed, Web of Science, EMbase, The Cochrane Library, Wanfang, and CNKI databases to search the related studies from inception to December 2021. The hazard ratio (HR) and 95% confidence interval (CI) were combined to evaluate the correlation of the preoperative SII with overall survival (OS), disease-free survival (DFS), and recurrence-free survival (RFS) in NSCLC patients. Results A total of 11 studies involving 9 180 patients were eventually included. The combined analysis showed that high SII levels were significantly associated with worse OS (HR=1.61, 95%CI 1.36-1.90, P<0.001), DFS (HR=1.50, 95%CI 1.34-1.68, P<0.001), and RFS (HR=1.17, 95%CI 1.04-1.33, P<0.001). Subgroup analyses also further verified the above results. Conclusion Preoperative SII is a powerful prognostic biomarker for predicting outcome in patients with operable NSCLC and contribute to prognosis evaluation and treatment strategy formulation. However, more well-designed and prospective studies are warranted to verify our findings.
