Reduction of membrane potential in GH3 cells with ghrelin
- VernacularTitle:Ghrelin对GH3细胞膜电位的作用
- Author:
Xuefeng HAN
;
Yunlong ZHU
;
Chen CHEN
- Publication Type:Journal Article
- Keywords:
ghrelin, patch-clamp, membrane potentail, growth hormone
- From:
Chinese Journal of Rehabilitation Theory and Practice
2005;11(11):927-928
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the in vitro effect of ghrelin on membrane membrane potentail of GH3 cells.MethodsNystatin-perforated whole-cell recording configuration was used.ResultsThe membrane potentail of GH3 was decreased from-(72±4.78) mV to(54.8±4.58) mV(P<0.01) after application of ghrelin(10-7～10-8 M)ConclusionGhrelin can transiently and significantly decreased the amplitude of membrane potentail,which may contribute to the ghrelin-stimulated GH secretion from GH3 cells.
