Influence of α-Zearalanol on lipometabolism and hemorheology in experimental hyperlipidemia rabbits
- VernacularTitle:α-玉米赤霉醇对实验性高脂血症兔的血脂代谢及血液流变学的影响
- Author:
Xiaoyuan ZHAO
;
Pingping ZUO
;
Jinhong DUAN
;
Yuan LU
;
Yihua ZHANG
;
Jinxuan CHENG
;
Yunqing WU
;
Jie LU
;
Renyu SUN
;
Shunling DAI
- Publication Type:Journal Article
- Keywords:
phytoestrogen, hyperlipidemia, lipometabolism, hemorheology, α-Zearalanol
- From:
Chinese Journal of Rehabilitation Theory and Practice
2005;11(11):924-926
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the effect of α-Zearalanol(α-ZAL) on lipometabolism and hemorheology in ovariectomized(OVX) hyperlipidemia rabbits.Methods44 adult virgin female rabbits were divided into 5 groups,group A: normal control;group B: sham+CHO;group C: OVX+CHO;group D: OVX+CHO+17βE_2;group E: OVX+CHO+α-ZAL.Cholesterol(CHO) was fed to rabbits for 12 weeks.Before and after feeding CHO,the serum lipid(TC,TG,LDL-C,HDL-C) were measured;Blood viscosity,plasma viscosity,aggregation index of RBC(AIRC) and fibrinogen were also assayed respectively.ResultsThe serum levels of TC,TG and LDL-C in group B and E were significantly decreased compared with those in group C(P<0.05);the level of blood viscosity,plasma viscosity and AIRC platelet aggregation rate in group D and E were also significantly decreased compared with those in group C(P<0.05).Conclusionα-ZAL can improve vascular function through the adjustment of lipometabolism and hemorheology.
