Short-term efficacy and safety of pembrolizumab combined with neoadjuvant chemotherapy for the treatment of non-small cell lung cancer

Yixing LI; Heng Zhao; Bohao Liu; Jizhao Wang; Yanpeng Zhang; Chendong Guo; Chuchen Zhao; Kun Fan; Hongyi Wang; Runyi Tao; Zhiyu Wang; Jia Zhang; Junke FU; Guangjian Zhang

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Short-term efficacy and safety of pembrolizumab combined with neoadjuvant chemotherapy for the treatment of non-small cell lung cancer

VernacularTitle:帕博利珠单抗联合新辅助化疗治疗非小细胞肺癌的近期疗效和安全性
Author: Yixing LI ^{1
,

2
,

3} ; Heng ZHAO ^{1
,

2
,

3} ; Bohao LIU ^{1
,

2
,

3} ; Jizhao WANG ^{1
,

2
,

3} ; Yanpeng ZHANG ^{1
,

2
,

3} ; Chendong GUO ^{3
,

4
,

5} ; Chuchen ZHAO ^{3
,

4
,

5} ; Kun FAN ^{1
,

2
,

3} ; Hongyi WANG ^{1
,

2
,

3} ; Runyi TAO ^{1
,

2
,

3} ; Zhiyu WANG ^{1
,

2
,

3} ; Jia ZHANG ^{1
,

2
,

3} ; Junke FU ^{1
,

2
,

3} ; Guangjian ZHANG ^{1
,

2
,

3}
Author Information

1. Department of Thoracic Surgery, The First Affiliated Hospital of Xi'
2. an Jiaotong University, Xi'
3. an, 710061, P. R. China
4. Xi'
5. an Jiaotong University Medical Department, Xi'
Publication Type:Journal Article
Keywords: Immune checkpoint inhibitors; programmed cell death-1; pembrolizumab; neoadjuvant immunotherapy; non-small cell lung cancer
From: Chinese Journal of Clinical Thoracic and Cardiovascular Surgery 2023;30(03):369-374
CountryChina
Language:Chinese
Abstract: Objective To explore the short-term efficacy and safety of pembrolizumab combined with chemotherapy in the neoadjuvant treatment of non-small cell lung cancer. Methods The clinical data of 11 male patients with non-small cell lung cancer who underwent pembrolizumab combined with neoadjuvant chemotherapy in the Department of Thoracic Surgery, the First Affiliated Hospital of Xi'an Jiaotong University from December 2019 to June 2021 were retrospectively analyzed. The average age of the patients was 52.0-79.0 (62.0±6.9) years. The imaging data and pathological changes before and after neoadjuvant treatment were compared, and adverse reactions during neoadjuvant treatment were recorded. Objective remission rate (ORR) and main pathological remission rate (MPR) and pathological complete remission rate (pCR) were the main observation endpoints. Results After preoperative neoadjuvant therapy with pembrolizumab combined with platinum or paclitaxel, all patients successfully underwent thoracoscopic radical resection of lung cancer. The ORR was 72.7%, and the MPR was 81.8%. Among them, 45.5% of patients achieved pCR. The main adverse reactions were hypoalbuminemia, decreased appetite and nausea. The mortality rate within 30 days after surgery was 0, and no tumor metastasis was observed. Conclusion Pembrolizumab combined with neoadjuvant chemotherapy is safe and feasible to treat non-small cell lung cancer, and the short-term efficacy is beneficial.