Prognostic value of serum cystatin C in patients with congenital heart disease-associated pulmonary arterial hypertension
- VernacularTitle:血清胱抑素 C 对先天性心脏病相关肺动脉高压患者的预后价值
- Author:
Feng ZHU
1
;
Aisan AIKEBAI
1
;
Maheshati TUNIKE
1
;
Ren TIAN
1
;
Yunxia LI
1
;
Teng YUAN
1
;
You CHEN
2
Author Information
1. The First Affiliated Hospital of Xinjiang Medical University, Urumqi, 830054, P. R. China
2. Heart Center, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, 830054, P. R. China Corresponding author: CHEN You, Email: donny666@sina.com
- Publication Type:Journal Article
- Keywords:
Congenital heart disease;
pulmonary arterial hypertension;
cystatin C;
all-cause death;
biomarker
- From:
Chinese Journal of Clinical Thoracic and Cardiovascular Surgery
2023;30(02):273-279
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the prognostic value of serum cystatin C (Cys C) in patients with congenital heart disease-associated pulmonary arterial hypertension (PAH-CHD). Methods A retrospective cohort study was conducted on adult PAH-CHD patients who were hospitalized for the first time in the First Affiliated Hospital of Xinjiang Medical University from January 2010 to January 2020. The serum Cys C and other related data of patients were collected. The median follow-up time was 57 months. The main end event was all-cause death. According to the prognosis, the patients were divided into a survival group and a death group. Cox regression was used to analyze the risk factors for all-cause death in patients with PAH-CHD. Results A total of 456 patients were enrolled, including 160 males and 296 females, aged 38.99±14.72 years. The baseline data showed that there were statistical differences in resting heart rate, serum Cys C, creatinine, NT-proB-type natriuretic peptide (NT-proBNP), high-sensitivity cardiac troponin T (hs-cTnT), high-sensitivity C reactive protein (hs-CRP), New York Heart Association (NYHA) cardiac function classification and serum potassium between the survival group and the death group. Univariate Cox regression analysis showed that serum Cys C, NT-proBNP, hs-cTnT, creatinine and NYHA cardiac function classification were related risk factors for all-cause death in patients with PAH-CHD. Multivariate Cox regression analysis showed that serum Cys C (HR=3.820, 95%CI 2.053-7.108, P<0.001), NYHA grade Ⅲ (HR=2.234, 95%CI 1.316-3.521, P=0.010), NYHA grade Ⅳ (HR=4.037, 95%CI 1.899-7.810, P=0.002) and NT-proBNP (HR=1.026, 95%CI 1.013-1.039, P<0.001) were independent risk factors for all-cause death in patients with PAH-CHD and had a good predictive value. Conclusion As a new cardiac marker, serum Cys C can predict all-cause death in patients with PAH-CHD and is an independent risk factor.
