Mechanism of Traditional Chinese Medicine in Prevention and Treatment of Parkinson's Disease：A Review
10.13422/j.cnki.syfjx.20231391
- VernacularTitle:中医药防治帕金森病的机制研究进展
- Author:
Xiaolong SHANG
1
;
Yu WANG
2
;
Chenchen XU
3
;
Jianjian DONG
3
;
Wenlong AI
3
;
Liangjie ZHANG
1
;
Chunling CI
1
;
Xun WANG
2
Author Information
1. Graduate School of Anhui University of Chinese Medicine，Hefei 230031，China
2. Affiliated Hospital of Institute of Neurology，Anhui University of Chinese Medicine，Hefei 230001，China
3. Institute of Neurology，Anhui University of Chinese Medicine，Hefei 230031，China
- Publication Type:Journal Article
- Keywords:
Parkinson's disease;
traditional Chinese medicine prevention and treatment;
Chinese medicinal extract;
mechanism of action;
research progress
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2023;29(17):248-259
- CountryChina
- Language:Chinese
-
Abstract:
Parkinson's disease （PD） is a progressive chronic neurodegenerative disorder with a complex pathogenesis involving oxidative stress， neuroinflammation， mitochondrial dysfunction， and other factors. Currently， the clinical treatment of PD mainly includes levodopa， dopamine receptor agonists， monoamine oxidase B inhibitors， catechol-O-methyltransferase inhibitors， and anticholinergic drugs， but there is a lack of disease-modif g therapies that can definitively improve disease progression. According to the understanding of traditional Chinese medicine （TCM）， PD is characterized by asthenia in origin and sthenia in superficiality. It is primarily caused by liver-kidney Yin deficiency， Qi-blood insufficiency， and closely related to wind， fire， phlegm， and blood stasis. Numerous clinical practices have shown that TCM has significant clinical value in the prevention and treatment of PD， the management of motor and non-motor symptoms， and the neuroprotection of dopaminergic neurons. The underlying mechanisms of TCM include antioxidative stress， anti-neuroinflammation， and regulation of mitochondrial dysfunction. This article categorized and summarized the pathogenesis of PD， systematically elucidated the pharmacological actions and molecular mechanisms of TCM monomer extracts and compounds in the prevention and treatment of PD， and provided the latest clinical research progress， aiming to provide references for the development and clinical use of TCM for PD.
