Cardiovascular Protective Effect of Shenmai Injection： A Review
10.13422/j.cnki.syfjx.20220790
- VernacularTitle:参麦注射液心血管保护作用的研究进展
- Author:
Xiaoyan HUANG
1
;
Xue FU
1
;
Yi DENG
1
;
Sisi LEI
1
;
Kun BAO
1
;
Bojun CHEN
1
Author Information
1. The Second Affiliated Hospital of Guangzhou University of Chinese Medicine，Guangzhou 510120，China
- Publication Type:Journal Article
- Keywords:
Shenmai injection;
cardiovascular protection;
myocardial action;
cardiovascular action;
blood rheology
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2023;29(17):237-247
- CountryChina
- Language:Chinese
-
Abstract:
With the improvement of people's living standards and the increasing aging population， the incidence of cardiovascular diseases has sharply risen， making it the leading cause of death and a major "killer" for humans. The prevention and treatment of cardiovascular diseases still face severe challenges. Shenmai injection （SMI）， a Chinese medicinal preparation， is widely used in the prevention and treatment of cardiovascular diseases because of its individualized advantages in syndrome differentiation and definite efficacy. Meanwhile， its pharmacological effects and related mechanism are becoming increasingly clear. Modern research shows that SMI can exert cardioprotective effects by reducing myocardial inflammatory response， alleviating oxidative stress， inhibiting myocardial cell apoptosis， improving microcirculatory dysfunction after myocardial ischemia-reperfusion， protecting mitochondrial structure and function， inhibiting ventricular remodeling， reducing drug-induced cardiotoxicity， and possessing antiviral properties. Additionally， it can produce cardiovascular protection by relaxing blood vessels， protecting endothelial cells， and promoting angiogenesis. Furthermore， SMI can lower blood viscosity and lipid levels， thus improving blood rheology. In the future， more clinical trials and basic research are needed to clarify its therapeutic efficacy and target mechanism to further confirm the effectiveness and safety of its clinical application.
