Pathogenesis of Metabolic Remodeling of Energy Substrate Based on Theory of Deficient Qi Stagnation and Progress of Chinese Medicine Intervention
10.13422/j.cnki.syfjx.202202328
- VernacularTitle:基于“虚气留滞”理论探析心肌能量底物代谢重构的病机与中药干预研究进展
- Author:
Jing LI
1
;
Senjie ZHONG
2
;
Huifang KUANG
1
;
Yang YANG
1
;
Yi LIU
1
;
Shuchun HUANG
1
;
Zhihua GUO
1
;
Qiuyan ZHANG
1
Author Information
1. Hunan University of Chinese Medicine， Changsha 410208， China
2. The First Affiliated Hospital of Guangzhou University of Chinese Medicine， Guangzhou 510405， China
- Publication Type:Journal Article
- Keywords:
heart failure;
substrate metabolic remodeling;
fatty acid metabolism;
glucose metabolism;
deficiency Qi stagnation;
Chinese medicine
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2023;29(17):195-202
- CountryChina
- Language:Chinese
-
Abstract:
In the case of cardiac dysfunction， energy metabolism changes and the metabolism of myocardial substrates is reconstructed， as manifested by variation in the selection and utilization of energy substrates such as fatty acids and glucose. Persistent metabolic disorders of substrates will decrease energy supply， thus resulting in the occurrence and development of heart failure. Metabolic remodeling of substrate is resulted from the decline of visceral function and the accumulation of pathological products. Deficient Qi stagnation is the core pathogenesis. Deficient Qi （heart Qi deficiency， insufficient energy） is the root cause， which exists in the whole disease course. Stagnation （phlegm， blood stasis， fluid， lipid toxic products， lactic acid， etc.） is the symptom， which evidences the aggravation of the disease. Deficient Qi and stagnation are intertwined and causal， which form a spiral vicious circle. The typical syndrome is excess resulted from deficiency and deficiency-excess in complexity. The treatment principle is reinforcing healthy Qi and tonifying deficiency， dredging and removing pathogen. At the early stage， the method of reinforcing healthy Qi and tonifying deficiency （benefiting Qi） should be used， and the method of dredging and removing pathogen （activating blood） can be applied according to the conditions of patients. At the middle and late stages， both reinforcing healthy Qi and tonifying deficiency （benefiting Qi and warming Yang） and dredging and removing pathogen （activating blood， resolving stasis， and excreting water） should be emphasized. Chinese medicine can be applied according to the pathogenesis， thereby promoting the utilization of fatty acids， glucose， and other substrates and reducing the accumulation of toxic products derived from metabolic remodeling of substrate. Thus， both the root cause and symptoms can be alleviated， further improving cardiac energy metabolism and heart function.
