Clinical effect of tolterodine on detrusor hyperreflexia of patients with spinal cord injury
- VernacularTitle:托特罗定治疗脊髓损伤后逼尿肌反射亢进疗效观察
- Author:
Zhi-han SUN
;
Hua GUAN
;
Jing SHI
- Publication Type:Journal Article
- Keywords:
tolterodine, spinal cord injury, detrusor hyperreflexia
- From:
Chinese Journal of Rehabilitation Theory and Practice
2004;10(10):608-609
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo evaluate th effect and safety of tolterodine on detrusor hyperreflexia of patients with spinal cord injury.Methods20 cases of spinal cord injury patients with detrusor hyperreflexia were treated with tolterodine (2mg, twice daily), and the data of urodynamics and voiding diary before and after treatment were evaluated.ResultsAfter 12 weeks of treatment, it showed a significant increase from baseline in mean voiding volume (P<0.01), functional bladder volume (P<0.05) and interval of voiding (P<0.01). The bladder volume at first contraction significantly increased from (62.62±36.37)ml to (126.75±34.64)ml (P<0.01), the maximal pressure of detrusor contraction significantly decreased from (74.81±28.60) cm H2O to (61.90±16.22) cm H2O (P<0.05), the maximal amplitude of wave significantly decreased from (47.24±30.42) cm H2O to (39.36±25.28) cm H2O.ConclusionTolterodine is effective and safety to detrusor hyperreflexia of patients with spinal cord injury, and has a better therapeutic compliance and less adverse reactions.
