Effect of tolterodine on 39 spinal cord injured patients with detrusor hyperreflexia
- VernacularTitle:托特罗定治疗脊髓损伤后逼尿肌反射亢进39例
- Author:
Gen-lin LIU
;
Ying ZHENG
;
Chun-xia HAO
;
Hongjun ZHOU
;
Yanhong HUANG
- Publication Type:Journal Article
- Keywords:
tolterodine, spinal cord injury (SCI), detrusor hyperreflexia
- From:
Chinese Journal of Rehabilitation Theory and Practice
2004;10(10):606-607
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo observe the efficacy and tolerability of tolterodine on spinal cord injured (SCI) patients with detrusor hyperreflexia.Methods39 cases were treated with tolterodine administration for at least two weeks (8.31±6.47 months in average), the range of drug dosage was 1 mg to 12 mg per day, 5.82±3.13 mg in average. Twelve of them have taken the drug (1-8 mg per day) for one year.ResultsAfter two weeks of treatment, 37 cases (94.87%) had a good effect, and the bladder volume increased 74.36±35.32 ml (P<0.001), the mean frequency of micturition decreased 3.85±2.38 times (P<0.001), urine of each micturition increased 49.74±41.20 ml (P<0.001), the residual urine increased 64.62±41.98 ml(P<0.001).Additionally, hydronephrosis of two cases was remitted. The adverse events: 8 cases of thirsty, 1 case of tachycardia and 1 case of urine retention.ConclusionTolterodine has a good effect and limited side effects on SCI patients with detrusor hyperreflexia.
