Effects of tolterodine on detrusor hyperreflexia for patients with spinal cord injury
- VernacularTitle:托特罗定治疗脊髓损伤后逼尿肌反射亢进的临床观察
- Author:
Dong LI
;
Limin LIAO
- Publication Type:Journal Article
- Keywords:
tolterodine, spinal cord injury, detrusor hyperreflexia
- From:
Chinese Journal of Rehabilitation Theory and Practice
2005;11(11):895-896
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo evaluate the efficacy and tolerance of tolterodine in treating detrusor hyperreflexia in patients with spinal cord injury.Methods50 patients of spinal cord injury patients with detrusor hyperreflexia were involved in this study.The data from voiding diary were evaluated 7 days before and after the patients being treated with tolterodine 2 mg twice daily.ResultsAfter 12 weeks of treatment,the functional bladder volume increased from(114.0±44.3) ml to(207.7±54.9) ml,the mean frequency of micturition decreased from(8.9±2.7) /d to(4.6±2.5) /d,the mean volume of incontinence decreased from(646.7±348.9) ml to(426.6±291.3) ml,the mean frequency of incontinence decreased from(7.8±3.1) /d to(4.8±3.2) /d,which were all statistically different before and after treatment.5 patients felt dry mouth,but they could tolerated it.ConclusionTolterodine is an effective and well tolerable antimuscarinic agent for treating detrusor hyperreflexia after spinal cord injury.
