Effect of Jiuqiang Naoliqing on the TXA_2 and PGI_2 level in spontaneous hypertension rat plasma
- VernacularTitle:久强脑立清对自发性高血压大鼠血浆血栓素A2和前列环素水平的影响
- Author:
Xiang-ying KONG
;
Ping-ping ZUO
;
Zhi-meng LI
;
Jinhong DUAN
;
Lingna KONG
;
Shunling DAI
- Publication Type:Journal Article
- Keywords:
Jiuqiang Naoliqing, spontaneous hypertension rat(SHR), thromboxane A2(TXA2), prostaglandin I2(PGI2)
- From:
Chinese Journal of Rehabilitation Theory and Practice
2004;10(9):518-519
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the effect of Jiuqiang Naoliqing(JNQ) on the TXA2 and PGI2 level in spontaneous hypertension rat (SHR) plasma.MethodsThe plasma was separated after the SHR and Wistar rats were treated with JNQ at the dose of 0.133g/kg,0.265g/kg,0.530g/kg and 1% carboxymethyl cellulose respectively for 5 weeks. The level of TXB2 and 6 keto PGF1α ,stable metabolin of TXA2 and PGI 2,in SHR plasma was tested by radioimmunoassay.ResultsThe level of TXB2 and the ratio of TXB2/6 keto PGF1α (T/P) in SHR plasma increased significantly(P<0.01),and there was no significant difference in the concentration of 6 keto PGF1α between Wistar rats and SHR plasma(P>0.05). JNQ could increase the generation of 6 keto PGF1α and decrease the level of TXB2 and T/P in SHR plasma after treated with different dosages for 5 weeks.ConclusionJNQ may improve the balance between TXA2 and PGI2 in SHR plasma.
