A New Study From Ivan de Araujo Lab Reported GLP-1 Mediated Gut-Brain Neural Circuit Controls Appetite Suppression
10.13471/j.cnki.j.sun.yat-sen.univ（med.sci）.2023.0424
- VernacularTitle:Ivan de Araujo团队揭示GLP-1如何通过肠脑轴神经环路调控机体行为和生理学效应
- Author:
Tong ZHANG
1
Author Information
1. Guangzhou First People’s Hospital//Guangzhou Digestive Disease Center//Department of General Surgery， The Second Affiliated Hospital of South China University of Technology， Guangzhou 510180， China
- Publication Type:Journal Article
- Keywords:
glucagon-like peptide-1;
anorexia;
gut-brain axis
- From:
Journal of Sun Yat-sen University(Medical Sciences)
2023;44(4):718-720
- CountryChina
- Language:Chinese
-
Abstract:
A new study in Cell from Ivan de Araujo and colleagues reported that intestinal GLP-1 acts on an inter-organ sympathetic neural circuit that induces appetite suppression. This study revealed that GLP-1， secreted by ileal L cells， sensing by intestinal myenteric layer intestinofugal neurons activated a sympatho-gastro-spinal-reticular-hypothalamic pathway involved in appetite suppression， linking stomach distention to craniofacial programs for food rejection. These molecularly indentified， delimited enteric circuits may be targeted to ameliorate the abdominal bloating and loss of appetite typical of gastric motility disorders.
