Relationship Between p53， EGFR and Radiotherapy Resistance of Head and Neck Squamous Cell Carcinoma
10.13471/j.cnki.j.sun.yat-sen.univ（med.sci）.2023.0408
- VernacularTitle:p53及EGFR与头颈部鳞癌放疗抵抗的关系
- Author:
Yong-jie DAI
1
;
Gang XU
1
Author Information
1. Department of Oncology and Radiotherapy， The Second School of Clinical Medicine， Jinan University， Shenzhen 518000，China
- Publication Type:Review
- Keywords:
p53;
epidermal growth factor receptor;
radiotherapy resistance
- From:
Journal of Sun Yat-sen University(Medical Sciences)
2023;44(4):596-600
- CountryChina
- Language:Chinese
-
Abstract:
Head and neck cancers are the seventh most common type of cancer in the world， among which more than 90% are squamous cell carcinomas（HNSCC）. Radiotherapy is one of the important treatments for HNSCC， and the sensitivity of tumor cells to the therapy is a key factor influencing the efficacy of treatment. p53 is one of the most common mutated genes in HNSCC， and epidermal growth factor receptor（EGFR） is overexpressed in many HNSCC. Both of these genes could enhance cellular DNA repair， which may be related to the radiotherapy resistance of HNSCC. This review focuses on the mechanisms by which tumor cells escape radiation-mediated apoptosis through p53 and EGFR-mediated DNA repair.
