Roles of Long Noncoding RNAs and Glycolysis in Digestive System Tumors
10.13471/j.cnki.j.sun.yat-sen.univ（med.sci）.2023.0407
- VernacularTitle:lncRNA与糖酵解在消化道肿瘤中的作用
- Author:
Xin-rui HOU
1
;
Xiao-ping WANG
1
Author Information
1. Key Laboratory of High Altitude Hypoxia Environment and Life Health， School of Medicine， Xizang Minzu University， Xianyang 712082， China
- Publication Type:Review
- Keywords:
digestive system tumor （DST）;
long noncoding RNAs （LncRNAs）;
glycolysis;
biomarkers;
therapy
- From:
Journal of Sun Yat-sen University(Medical Sciences)
2023;44(4):587-595
- CountryChina
- Language:Chinese
-
Abstract:
Long noncoding RNAs （LncRNAs）， a class of noncoding RNAs greater than 200 bases in length， are widely involved in the initiation， progression and glycolytic processes of many tumors， and can act as competitive endogenous RNA sponges to absorb miRNAs. LncRNAs can also inhibit miRNA expression， thereby regulate the glycolysis of tumor cells， affects cell proliferation， invasion and other biological activities. This review explores the roles of LncRNAs and glycolysis in digestive system tumors （DST）， a representative group of malignant tumors. Extending the LncRNA role in the diagnosis， treatment and prognosis of other tumors， we conclude that LncRNAs have the potential to be new candidate genes for tumorigenesis and serve as tumor biomarkers， which provides new insight into morbidity and mortality decrease of DST and other tumors.
