PANoptosis： Molecular Mechanism of Action and Effects on Blinding Eye Diseases
10.13471/j.cnki.j.sun.yat-sen.univ（med.sci）.2023.0405
- VernacularTitle:PANoptosis 的分子作用机制及其在致盲性眼病中的作用
- Author:
Qing-qing LI
1
;
Lian LIU
1
Author Information
1. Department of Ophthalmology， The First Affiliated Hospital of Jinan University， Guangzhou 510630， China
- Publication Type:Review
- Keywords:
PANoptosis;
apoptosis;
necroptosis;
pyroptosis;
blinding eye diseases
- From:
Journal of Sun Yat-sen University(Medical Sciences)
2023;44(4):576-581
- CountryChina
- Language:Chinese
-
Abstract:
Previous studies focused on the unique regulatory mechanisms of different cell death pathways. However， recent studies highlight crosstalk and co-ordination between these pathways and initiate a new cell death process called PANoptosis （pyroptosis， apoptosis， necroptosis）. PANoptosis is an inflammatory programmed cell death pathway regulated by the PANoptosome complex with critical features of pyroptosis， and/or necroptosis but cannot be characterized by any of the death modes of pyroptosis， apoptosis or necroptosis alone. By activating the PANoptosis pathway， some triggers like bacterial， viral， and fungal infections can cause death of the host. This review explains the PANoptosis-related routes， regulators and their potential effects on blinding eye diseases.
