Cardiomyocyte Energy Metabolism in Mammalian Cardiac Regeneration
10.13471/j.cnki.j.sun.yat-sen.univ（med.sci）.2023.0403
- VernacularTitle:哺乳动物心肌代谢与心脏再生
- Author:
Jing TAN
1
;
Wei-bin CAI
1
Author Information
1. Department of Biochemistry and Molecular Biology， Zhongshan School of Medicine， Sun Yat-sen University
- Publication Type:Review
- Keywords:
cardiomyocyte energy metabolism;
cardiac regeneration;
metabolic reprogramming;
myocardial injury and repair
- From:
Journal of Sun Yat-sen University(Medical Sciences)
2023;44(4):560-569
- CountryChina
- Language:Chinese
-
Abstract:
Cardiovascular disease， such as coronary heart disease and acute myocardial infarction， is a leading cause of death globally. Due to the limited proliferative and regenerative capacity of adult mammalian cardiomyocytes （CMs）， any of the current therapies cannot reverse the massive loss of CMs and subsequent fibrosis resulting from cardiac injury. Mammals mainly rely on glycolysis in the embryonic stage and fatty acid oxidation after birth for energy production. Recent reports have indicated that this metabolic pattern switch is closely related to the loss of CM proliferation. In this review， we summarize the biological characteristics of CMs and advances in heart regeneration， meanwhile shed light on the important role of CMs energy metabolism in cardiac regeneration.
