Metaflammation and Development of Diabesity
10.13471/j.cnki.j.sun.yat-sen.univ（med.sci）.2023.0401
- VernacularTitle:代谢性炎症反应与糖胖病的发生发展
- Author:
Yan-ming CHEN
1
Author Information
1. Department of Endocrinology & Metabolism， Guangdong Provincial Key Laboratory of Diabetology， The Third Affiliated Hospital of Sun Yat-sen University， Guangzhou 510630
- Publication Type:Journal Article
- Keywords:
diabesity;
metaflammation;
immune;
overweight and obesity
- From:
Journal of Sun Yat-sen University(Medical Sciences)
2023;44(4):544-550
- CountryChina
- Language:Chinese
-
Abstract:
Type 2 Diabetes occurring in the context of obesity is a term called diabesity， of which clinical outcome is more serious and complicated. Metaflammation is the main reason that causes insulin resistance and eventually leads to diabesity development. In this review， the author discusses the initiating factors that triggers metaflammation， and how this drives insulin resistance. This review also demonstrates our current work on pathogenesis of diabesity from the perspective of “gut microbiota-immune-metabolic axis”， as well as exploring effective treatments for diabesity through combination of body weight and glycemic control. In the end， the review briefly summarizes the "3+N" model for the treatment of diabesity and its complications from a multidisciplinary team （MDT） of the Third Affiliated Hospital of Sun Yat-sen University， providing one-stop comprehensive management services for patients.
