Immunological effect and influencing factors of HAART on HIV/AIDS with baseline CD4 below 350 cells/mm3
- VernacularTitle:基线CD4低于350个/mm3的HIV/AIDS抗病毒治疗免疫学效果及其影响因素分析
- Author:
Dingyuan ZHAO
1
;
Heng TANG
1
;
Wu ZHENG
1
;
Yanmeng FENG
1
;
Huiping CHEN
1
;
Honglin JIANG
1
Author Information
- Publication Type:Journal Article
- Keywords: HIV/AIDS; HAART; CD4+T cel
- From: Journal of Public Health and Preventive Medicine 2023;34(4):51-54
- CountryChina
- Language:Chinese
- Abstract: Objective To analyze the immunological effect and its influencing factors of HAART on HIV/AIDS with a baseline CD4 of less than 350 cells/mm3 in Hubei Province during 2011-2020. Methods The treatment information of people living with HIV/AIDS (PLWH) was collected through China Disease Control and Prevention Information System, and the change of CD4 mean value was analyzed by Wilcoxon sign rank sum test. Chi square test and multivariate logistic regression were used to analyze the factors influencing the immunological effect. Results The mean value of CD4 cell count at baseline was (172.78±107.65) cells/mm3 before treatment and (398.85±206.71) cells/mm3 in the fifth year after treatment. Patients with baseline CD4<50 /mm3 had the largest increase in CD4 mean value after treatment (P<0.05). Multivariate logistic regression analysis showed that Age ≥35 years, heterosexual transmission, time interval from diagnosis to treatment≥1 month, baseline CD4<50 /mm3, treatment time 7-<18 months, and drug failure were the risk factors for the success of antiviral therapy(P<0.05). Conclusion The immunological effect of HIV/AIDS antiviral therapy in Hubei Province is affected by many factors. It is necessary to strengthen the implementation of early detection and early treatment strategy and promote treatment compliance education for patients aged ≥35 years.
