Tualang Honey Potentially Delay Deterioration in  Haematological and Immunological Parameters in  Asymptomatic, Treatment-naïve HIV-infected Patients

Tang Suk Peng; Che Badariah Abdul Aziz; Mahiran Mustafa; Maizan Mohamed; Wan Nazirah Wan Yusuf

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Tualang Honey Potentially Delay Deterioration in Haematological and Immunological Parameters in Asymptomatic, Treatment-naïve HIV-infected Patients

Author: Tang Suk Peng ¹ ; Che Badariah Abdul Aziz ² ; Mahiran Mustafa ³ ; Maizan Mohamed ⁴ ; Wan Nazirah Wan Yusuf ^{1
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1. Department of Pharmacology, School of Medical Sciences, Health Campus, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia&
2. Department of Physiology, School of Medical Sciences, Health Campus, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia
3. Infectious Disease Unit, Hospital Raja Perempuan Zainab II, 15200 Kota Bharu, Kelantan
4. Faculty of Veterinary Medicine, Universiti Malaysia Kelantan, Pengkalan Chepa, 16100 Kota Bharu, Kelantan
5. Hospital Universiti Sains Malaysia, Health Campus, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia
Publication Type:Journal Article
Keywords: Tualang honey, HIV, Asymptomatic, Haematological parameters, Immunological parameters
From:Malaysian Journal of Medicine and Health Sciences 2021;17(No.4):166-173
CountryMalaysia
Language:English
Abstract: Introduction: This report aimed to assess the effects of administration of Tualang honey for six months duration on the haematological and immunological parameters in treatment-naïve HIV-infected patients who were asymptomatic. Methods: This was a randomised, controlled, open-labelled study. A total of 95 asymptomatic HIV-positive subjects with low CD4 counts of 250-600 cells/mm3 and not on antiretroviral therapy were recruited. Tualang honey was administered at 20 g each, once daily (HLD; total of 20 g honey), twice daily (HID; total of 40 g honey) or thrice daily (HHD; total of 60 g honey) for six months period. Control (CT) group did not receive any honey supplementation. Haematological and immunological parameters were measured at baseline, three-month and six-month follow-up. The differences within the group (time effect) and between the groups (regardless of time) for all four groups were analysed using Repeated Measures ANOVA followed by a post-hoc test. Results: A significant reduction in total white blood cell, neutrophil and lymphocyte counts were observed at six-month follow-up in CT and HLD groups when compared to baseline. The immunological parameters showed similar trend of reduction in the CT and HLD groups. Meanwhile, the measured parameters were relatively maintained in HID and HHD groups at six-month period when compared to baseline. Conclusion: Tualang honey supplementation at intermediate and high doses for six months delay the deterioration of haematological and immunological parameters in asymptomatic, treatment-naïve HIV subjects.
Full text:11.2021my1134.pdf