Effect of Erigeron breviscapus Hand-Mazz on learning and memory dysfunction in mice with cerebral ischemia/reperfusion injury
- VernacularTitle:灯盏花注射液对反复缺血再灌脑损伤小鼠学习记忆功能的影响
- Author:
Guo-qing TIAN
;
He-qi LU
;
Sai-shan GUO
- Publication Type:Journal Article
- Keywords:
Erigeron breviscapus Hand Mazz, learning and memory, ischemia/reperfusion, mice
- From:
Chinese Journal of Rehabilitation Theory and Practice
2004;10(7):404-405
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of Erigeron breviscapus Hand Mazz(EBH) on learning and memory dysfunction in mice with cerebral ischemia/reperfusion injury.Methods 40 mice were randomly divided into control group, sham operated group, model group and EBH group, with 10 mice each. Mice model of cerebral ischemia/reperfusion injury was established by bilateral common carotid artery blocking. 7 days before and after operation, the mice in EBH group were injected I.p.with EBH injection 0.15 ml/d, while those in other groups were injected I.p. with saline 0.15 ml/d. The learning and memory function was tested by Morris water maze.Results The latent period in the model group was longer than that in the normal group and the sham operated group (P<0.05). EBH could shorten the latent period significantly as compared with those in the model group (P<0.05).Conclusion EBH can improve learning and memory function in cerebral ischemia/reperfusion injured mice.
