Effect of Schwann cells transplanting into injured middle brain on remyelination in rat
- VernacularTitle:Schwann细胞移植对电针损伤大鼠中脑新生髓鞘的影响
- Author:
Hong WAN
;
Jing ZHAI
;
Jun-hua LI
;
Yazhuo ZHANG
;
Zhongcheng WANG
- Publication Type:Journal Article
- Keywords:
Schwann cell, middle brain, remyelination, cells transplantation
- From:
Chinese Journal of Rehabilitation Theory and Practice
2004;10(7):387-388
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the remyelination after Schwann cells grafted into injured middle brain in rat.Methods Schwann cells originated from sciatic nerves of 1 to 2 day old rat were expanded and labeled by BrdU in vitro, transplanted into the rat middle brain injured by electric needle stimulus. Immunohistochemistry and myelin staining were used to locate in the BrdU positive cells and investigate remyelination.Results BrdU positive cells could be identified till at least 8 months after grafting, which mainly migrated toward injured ipsilateral cortex. New myelination could be seen in destructed brain stem area. Conclusion Schwann cells transplantation could promote CNS regeneration.
