A preliminary study on the safety, efficacy and acceptability of the community preparation of Siling Labuyo (Capsicum frutescens) Liniment in the management of Knee Osteoarthritis in a six-week, active-controlled community-based clinical trial
https://doi.org/10.47895/amp.v53i4.52
- Author:
Elizabeth R. Paterno
1
;
Clarisse A. Pangilinan
2
;
Erna C. Arollado
2
;
Rachael Marie B. Rosario
1
Author Information
1. Department of Family and Community Medicine, College of Medicine and Philippine General Hospital, University of the Philippines Manila
2. Institute of Pharmaceutical Sciences, National Institutes of Health, University of the Philippines Manila
- Publication Type:Journal Article
- Keywords:
Capsicum frutescens
- MeSH:
Diclofenac;
Osteoarthritis, Knee;
Pain
- From:
Acta Medica Philippina
2019;53(4):327-334
- CountryPhilippines
- Language:English
-
Abstract:
Objective:The study determined the safety, efficacy and acceptability of a Philippine community preparation of Siling Labuyo liniment in the management of knee osteoarthritis.
Methods:A 6-week randomized, double-blind, active-controlled clinical trial was conducted in three municipalities of Cavite from 2017-2018. The municipalities were randomly assigned to either the control or experimental group, using a commercially available Diclofenac 1% gel as the control agent. Knee Injury and Osteoarthritis Outcome Score (KOOS) and Pain Visual Analogue Scale (VAS) were used to measure the outcomes.
Results:Forty-seven participants completed the study. Statistically significant improvement (p<0.05) in pain relief, reduction of symptoms and increase in knee functionality was reported by participants in both the experimental and control groups. Across the dimensions measured, at least 30% improvement in scores was reported by the experimental group, and at least 40% by the control group. The difference was statistically not significant (p>0.05). Itching (13%), burning sensation (11%) and reddening of the skin (15%) were experienced in both the experimental and the active control groups.
Conclusion:Use of the liniment led to a modest therapeutic effect and was well-tolerated by the participants.
- Full text:52-Article Text-226-1-10-20190904.pdf
