Role and potential significance of peroxisome proliferator-activated receptors in liver diseases
10.3969/j.issn.1001-5256.2023.07.034
- VernacularTitle:过氧化物酶体增殖物激活受体(PPAR)在肝脏疾病中的作用及潜在意义
- Author:
Shuaixia FENG
1
;
Ying XU
1
;
Han HAN
1
Author Information
1. School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
- Publication Type:Review
- Keywords:
Peroxisome Proliferator-Activated Receptors;
Liver Diseases;
Inflammation
- From:
Journal of Clinical Hepatology
2023;39(7):1747-1753
- CountryChina
- Language:Chinese
-
Abstract:
Peroxisome proliferator-activated receptors (PPAR) are members of the nuclear estrogen receptor family, and they are involved in a variety of physiological and pathological processes in the human body and play important roles in cellular metabolism, inflammation, and cancer. At present, there are three known subtypes of PPAR, i.e., α, β/δ, and γ. Studies have shown that PPARs are highly expressed in the liver and are widely involved in various physiological and pathological activities such as liver energy metabolism, oxidative stress, and inflammation, and they are also closely associated with the progression of liver diseases. This article reviews the role of PPAR in common liver diseases such as viral hepatitis, metabolic associated fatty liver disease, cholestatic liver disease, liver fibrosis, and primary liver cancer, and the current status of their application in the treatment of liver diseases.
