Role of lipopolysaccharide in the development and progression of liver cancer
10.3969/j.issn.1001-5256.2023.07.032
- VernacularTitle:脂多糖在肝癌发生发展中的作用
- Author:
Tao WANG
1
;
Quan WANG
1
;
Lihua SONG
2
;
Xuezhang DUAN
1
Author Information
1. Department of Medical Oncology, The Fifth Medical Center of Chinese PLA General Hospital, Beijing 100039, China
2. College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100089, China
- Publication Type:Review
- Keywords:
Liver Neoplasms;
Gastrointestinal Microbiome;
Lipopolysaccharides;
Bacteria
- From:
Journal of Clinical Hepatology
2023;39(7):1734-1739
- CountryChina
- Language:Chinese
-
Abstract:
Liver cancer is an important public health issue worldwide. With the improvements in high-throughput sequencing and gene editing techniques in recent years, studies have further revealed the biological mechanism of intestinal microflora in the development, progression, and metastasis of liver cancer via the gut-liver axis, and in particular, it has been found that lipopolysaccharide, a component of the outer membrane of gram-negative bacteria, can cause downstream immune cascade reactions. This article reviews the possible mechanism of action of intestinal microflora lipopolysaccharide in the development and progression of liver cancer from the aspects of the association between intestinal environmental changes and liver cancer, immunoregulation by lipopolysaccharide, and preclinical treatment.
