Role of the nuclear factor erythroid 2-related factor 2/heme oxygenase-1 signaling pathway in alcoholic liver disease
10.3969/j.issn.1001-5256.2023.07.028
- VernacularTitle:核因子E2相关因子2/血红素加氧酶-1(Nrf2/HO-1)信号通路在酒精性肝病中的作用
- Author:
Cheng MA
1
;
Hui YANG
2
Author Information
1. Graduate School of Shanxi Medical University, Taiyuan 030001, China
2. Department of Infectious Diseases, The First Hospital of Shanxi Medical University, Taiyuan 030001, China
- Publication Type:Review
- Keywords:
Liver Diseases, Alcoholic;
NF-E2-Related Factor 2;
Heme Oxygenase-1;
Signal Transduction
- From:
Journal of Clinical Hepatology
2023;39(7):1708-1713
- CountryChina
- Language:Chinese
-
Abstract:
The incidence rate of alcoholic liver disease (ALD) is increasing year by year China, and there is a gradual increase in disease burden among Chinese people. Oxidative stress response in hepatocytes is an important pathogenic mechanism of ALD. The nuclear factor erythroid 2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1) signaling pathway is an important endogenous anti-oxidative stress pathway in the body, and Nrf2 is activated in response to oxidative stress and exerts its transcriptional activity to induce high HO-1 expression. HO-1 is an important oxidative stress response protein and plays a role in anti-inflammation, anti- oxidation, and cell apoptosis regulation together with heme hydrolysis products (bilirubin, carbon monoxide, and iron). This article reviews the research advances in the role of the Nrf2/HO-1 signaling pathway in ALD in recent years, so as to find a theoretical basis for the development and progression of ALD and an entry point for treatment.
