Research advances in ferroptosis in the pathogenesis and treatment of nonalcoholic fatty liver disease
10.3969/j.issn.1001-5256.2023.07.025
- VernacularTitle:铁死亡在非酒精性脂肪性肝病发病和治疗中的作用
- Author:
Longyun WU
1
;
Xiaolan LU
1
Author Information
1. Department of Gastroenterology, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai 201399, China
- Publication Type:Review
- Keywords:
Ferroptosis;
Iron Metabolism Disorders;
Non-alcoholic Fatty Liver Disease;
Lipid Peroxidation;
Drug Therapy
- From:
Journal of Clinical Hepatology
2023;39(7):1687-1695
- CountryChina
- Language:Chinese
-
Abstract:
Ferroptosis is a pattern of non-apoptotic cell death characterized by iron dependence and lipid peroxidation. Nonalcoholic fatty liver disease (NAFLD) is a metabolic disease with fat infiltration as its main pathological feature, and it is closely associated with insulin resistance and genetic susceptibility. The mechanism of transition from hepatic steatosis alone to steatohepatitis remains unclear, and studies have shown that ferroptosis in hepatocytes may be the trigger for the inflammatory initiation of steatohepatitis. This article reviews the role of abnormal iron metabolism and lipid peroxidation in promoting the development and progression of NAFLD and summarizes the application prospect of ferroptosis-related inhibitors in the treatment of NAFLD.
