Mechanism of action of lipotoxicity in nonalcoholic steatohepatitis
10.3969/j.issn.1001-5256.2023.07.024
- VernacularTitle:脂毒性在非酒精性脂肪性肝炎中的作用机制
- Author:
Guoguo ZHI
1
;
Jie MU
1
;
Bingjie SHAO
1
;
Dong WANG
1
Author Information
1. School of Basic Medical Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China
- Publication Type:Review
- Keywords:
Nonalcoholic Steatohepatitis;
Lipotoxicity;
Inflammation;
Apoptosis
- From:
Journal of Clinical Hepatology
2023;39(7):1681-1686
- CountryChina
- Language:Chinese
-
Abstract:
Nonalcoholic steatohepatitis (NASH) is an important part of the exacerbation of nonalcoholic fatty liver disease (NAFLD), and inflammation and liver damage are important pathological features of this stage. As one of the pathogenic mechanisms of NASH, lipotoxicity can regulate liver inflammation and hepatocyte apoptosis through multiple pathways. Therefore, this article elaborates on the specific regulatory mechanism of lipotoxicity on NASH from the two aspects of inflammation and hepatocyte apoptosis, which involves a variety of liver nonparenchymal cells and various signaling pathways such as JNK, NF-κB, and caspase-mediated cell apoptosis, so as to provide new ideas for the diagnosis and treatment of NASH in clinical practice.
