Role of purine signaling in liver immune regulation
10.3969/j.issn.1001-5256.2023.06.036
- VernacularTitle:嘌呤信号在肝脏免疫调节中的作用
- Author:
Faxiang MA
1
;
Zhengkun TU
1
Author Information
1. Laboratory of Tumor Immunology, The First Hospital of Jilin University, Changchun 130021, China
- Publication Type:Review
- Keywords:
Liver Diseases;
Adenosine Triphosphate;
Inflammation;
Immunomodulation
- From:
Journal of Clinical Hepatology
2023;39(6):1488-1496
- CountryChina
- Language:Chinese
-
Abstract:
Purines are mainly composed of ATP, NAD + , and nucleic acid. In addition to their key intracellular functions, NAD + , ATP, and their hydrolyzed products (including ADP, AMP, and adenosine) are important extracellular signals involved in physiological processes and pathological conditions. Purine signaling plays an important role in immune regulation of liver microenvironment. This article mainly summarizes the regulatory effect of purine signaling on immune cells in the liver and the effect of purine signaling on the progression of liver diseases by regulating the inflammatory and anti-inflammatory responses of immune cells in the liver.
