Role of intrahepatic microenvironment induced-autophagy in nonalcoholic fatty liver disease
10.3969/j.issn.1001-5256.2023.06.029
- VernacularTitle:肝内微环境诱导的自噬在非酒精性脂肪性肝病中的作用
- Author:
Xuanxuan KOU
1
;
Hua ZHANG
1
;
Jingxin DENG
1
;
Jiangang ZHANG
1
Author Information
1. Institute of Pathology, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, China
- Publication Type:Review
- Keywords:
Non-alcoholic Fatty Liver Disease;
Autophagy;
Cellular Microenvironment
- From:
Journal of Clinical Hepatology
2023;39(6):1440-1445
- CountryChina
- Language:Chinese
-
Abstract:
Nonalcoholic fatty liver disease (NAFLD) is a series of abnormal liver lesions mainly characterized by excessive lipid deposition in hepatocytes, and it is also the most common chronic liver disease worldwide. Autophagy is a basic cellular process in which cells degrade their own components and participate in the maintenance of organ function and body homeostasis, and it is closely associated with the progression of NAFLD. High fat, hypoxia, and stress in human body may cause abnormal changes in extracellular microenvironment in the liver, and such abnormal microenvironment may promote the development and progression of NAFLD by inducing liver cell autophagy. This article reviews the role and mechanism of autophagy of liver cells such as hepatocytes, Kupffer cells, and hepatic stellate cells in the progression of NAFLD based on various microenvironment characteristics in the liver.
