Association of inhibitory receptor T-cell immunoglobulin and immunoreceptor tyrosine-based inhibitory motif domain with immune disorders in chronic HBV infection
10.3969/j.issn.1001-5256.2023.06.026
- VernacularTitle:抑制性受体TIGIT与慢性HBV感染中免疫紊乱的关系
- Author:
Yuxia ZHOU
1
;
Caihong WANG
1
,
2
;
Xiaowen YAO
1
;
Rong WANG
1
;
Xiaofeng ZHENG
3
;
Xiaohui YU
2
;
Jiucong ZHANG
2
Author Information
1. The First Clinical Medical College of Gansu University of Chinese Medicine, Lanzhou 730030, China
2. Department of Gastroenterology, The 940 Hospital of Joint Logistic Support Force of PLA, Lanzhou 730050, China
3. Department of Gastroenterology, The Second Hospital of Lanzhou University, Lanzhou 730030, China
- Publication Type:Review
- Keywords:
Hepatitis B virus;
Receptors, Immunologic;
Immune Disorder
- From:
Journal of Clinical Hepatology
2023;39(6):1418-1423
- CountryChina
- Language:Chinese
-
Abstract:
Persistent HBV infection alters the expression of receptors on the surface of innate and acquired immune cells, which may cause a variety of immune disorders and finally lead to immune escape and disease chronicity. Studies have shown that the upregulation of inhibitory receptors is the main cause of immune disorders in patients, and blocking inhibitory receptors can restore immune function to a certain extent. T-cell immunoglobulin and immunoreceptor tyrosine-based inhibitory motif domain (TIGIT) is a new type of inhibitory receptor attracting much attention at present, and it is highly expressed in NK cells and T cells. It has been found that TIGIT plays an important role in chronic viral infection, and this article briefly reviews the research advances in the association between TIGIT and immune disorders in chronic HBV infection.
