Clinical efficacy and mechanism of action of kidney-tonifying, spleen-strengthening, and diuresis-promoting therapy in treatment of chronic hepatitis B
10.3969/j.issn.1001-5256.2023.06.003
- VernacularTitle:补肾健脾利湿法治疗慢性乙型肝炎临床效果及相关机制研究
- Author:
Xiaojun ZHU
1
;
Jinghao ZHANG
1
;
Xuehua SUN
1
;
Xin ZHANG
2
;
Yueqiu GAO
1
Author Information
1. Department of Hepatopathy, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
2. Laboratory of Cellular Immunity, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
- Publication Type:Discussions by Experts
- Keywords:
Hepatitis B, Chronic;
Reinforcing Kidney;
Strengthening Spleen;
Removing Dampness and Turbid
- From:
Journal of Clinical Hepatology
2023;39(6):1274-1279
- CountryChina
- Language:Chinese
-
Abstract:
Chronic hepatitis B is a public health issue worldwide. Nucleotide analogues and interferon therapy can effectively inhibit HBV replication, but they still have the shortcomings such as inability to achieve the clearance of HBV cccDNA and low HBsAg clearance rate. The academic viewpoint of "kidney-tonifying therapy for chronic hepatitis B" provides new ideas and methods for the treatment of hepatitis B. During long-term clinical practice, Department of Hepatology in Shuguang Hospital has identified that "deficiency of spleen and kidney with damp heat remaining" is the key pathogenesis of the continuous progression of chronic hepatitis B and has established the treatment regimen for chronic hepatitis B with the basic treatment method of tonifying the kidney, strengthening the spleen, and promoting diuresis. The clinical research of National Science and Technology Major Project from The 11th Five Year Plan to The 13th Five Year Plan has validated the clinical efficacy of this regimen and clarified that regulating the immune function of the body is the main mechanism of the kidney-tonifying, spleen-strengthening, and diuresis-promoting therapy in the treatment of chronic hepatitis B.
