Research progress of NOD2-mediated signaling pathways and relationship with autoinflammatory diseases and its inhibitors
10.16438/j.0513-4870.2022-1303
- VernacularTitle:NOD2介导的信号通路及其与自身炎症性疾病关系以及抑制剂研究进展
- Author:
Xi-yue YANG
;
Cai-ying YE
;
Lei ZHU
- Publication Type:Research Article
- Keywords:
nucleotide-binding oligomerization domain containing 2;
receptor-interacting protein 2;
autoinflammatory disease;
inhibitor;
autophagy;
endoplasmic reticulum stress
- From:
Acta Pharmaceutica Sinica
2023;57(4):899-908
- CountryChina
- Language:Chinese
-
Abstract:
Nucleotide-binding oligomerization domain containing protein 2 (NOD2) is a member of intracellular pattern recognition receptor. After being activated, it will induce the release of inflammatory factors through a series of signal cascade transduction, thus playing an important role in the innate immune response. The abnormal NOD2 signaling pathway is involved in the occurrence and development of many diseases, especially the single nucleotide polymorphisms (SNPs) of the NOD2 gene have been identified to be closely associated with autoinflammatory diseases (AIDs). Therefore, inhibitors targeting NOD2 pathway have great potential in the treatment of inflammatory immune diseases. This review presents the recent progress of NOD2 receptor-mediated signal transduction pathways and its regulation mechanisms, the relationship between NOD2 and AIDs, and the inhibitors of NOD2 pathway.
