Research progress on the development of human neutrophil elastase inhibitors
10.16438/j.0513-4870.2022-1116
- VernacularTitle:人中性粒细胞弹性蛋白酶抑制剂的研究进展
- Author:
Zhong-wei WANG
;
Hui WEN
;
Yu-chen WANG
;
Hua-qing CUI
- Publication Type:Research Article
- Keywords:
human neutrophil elastase;
human neutrophil elastase mechanism;
human neutrophil elastase physiological effect;
human neutrophil elastase inhibitor
- From:
Acta Pharmaceutica Sinica
2023;58(4):909-918
- CountryChina
- Language:Chinese
-
Abstract:
Human neutrophil elastase (hNE) is a serine proteolytic enzyme mainly distributed in neutrophils. When the balance between anti-hNE protein and hNE is broken, excessive release of hNE can cause the occurrence of various diseases. Therefore, inhibition of hNE is a promising therapeutic strategy. In this paper, the structure, action mechanism, physiological function of hNE and the development of hNE inhibitors were briefly summarized, in order to provide information for the related research.
