Research progress in bioanalysis and pharmacokinetics of liposome nanomedicine
10.16438/j.0513-4870.2022-1085
- VernacularTitle:脂质体纳米药物制剂的生物分析方法及药代动力学研究进展
- Author:
Yi LIU
1
;
Yu-jie ZHANG
1
;
Zi-yu WANG
2
;
Jian-song YOU
2
;
Lei YIN
1
;
Mei-yun SHI
1
,
3
Author Information
1. School of Life and Pharmaceutical Sciences, Dalian University of Technology, Panjin 124221, China
2. Aim Honesty Biopharmaceutical Co. Ltd., Dalian 116100, China
3. Aim Honesty Biopharmaceutical Co. Ltd., Dalian 116100, China
- Publication Type:Research Article
- Keywords:
liposome nanomedicine;
pretreatment method;
release drug;
biological analytical method;
pharmacokinetics
- From:
Acta Pharmaceutica Sinica
2023;58(4):834-843
- CountryChina
- Language:Chinese
-
Abstract:
Liposome nanomedicine is a new drug preparation with nano scale, which is encapsulated by lipid bilayer vesicle structure. As a drug delivery carrier, liposome has many advantages such as good biocompatibility, biodegradation in vivo and strong targeting. The application of liposome nano drug delivery system can improve the pharmacokinetic behavior and efficacy of some drugs in vivo to a certain extent, and reduce toxic and side effects. After liposome nanomedicine enter into the body, free drugs will be released, so there will be loaded drugs and free drugs in the body. Loaded drugs are drug repositories, free drugs are related to their efficacy and adverse reactions. Therefore, the pharmacokinetics study of liposomes should focus on both loaded drugs and free drugs. Quantitative analysis of free drugs, liposome particles and their materials is a big challenge. The bioanalysis and pharmacokinetics of liposome nanomedicines will be introduced and discussed in this review. We hope this review will provide a reference for the development of liposome nanomedicine.
