Progresses and analysis in fibrinolytic drugs induced hemorrhage
10.16438/j.0513-4870.2023-0526
- VernacularTitle:纤溶药物出血机制的进展及分析
- Author:
Ming-qing TANG
;
Cheng-jia HU
;
Rui-an XU
- Publication Type:Research Article
- Keywords:
thrombus;
fibrinolytic;
hemorrhage;
metalloproteinase;
serine protease
- From:
Acta Pharmaceutica Sinica
2023;58(6):1521-1527
- CountryChina
- Language:Chinese
-
Abstract:
At present, most clinical thrombolytic drugs are plasminogen activators, which are highly dependent on the plasminogen level of the patient. Therefore, the efficacy of those drugs is restricted. Unlike the conventional thrombolytic plasminogen activator drugs, fibrinolytic drugs have direct fibrinolytic activity. Thus, fibrinolytic drugs can directly dissolve the thrombus, and its thromlysis efficacy is not restricted by the patients' plasminogen. This is a new type of thrombolytic drug with higher thrombolytic efficiency and safety, and has become one of the research hotspots at present. Although more and more agents that can be used as fibrinolytic drugs have been discovered, only a few of them can successfully be applied in clinical practice. The mainly underlying reason is the risk of bleeding. In this paper, based on the latest research progress of fibrinolytic drugs, the bleeding mechanisms and coping strategies of fibrinolytic drugs were systematically reviewed, five types of bleeding mechanisms of fibrinolytic drugs were summarized, and three types of coping strategies were proposed. We hope our work can provide theoretical basis for the development of safer and more efficient fibrinolytic drugs.
