Two new ursane triterpenoids from Agastache rugosa (Fisch. et.Mey.) O. Kuntze
10.16438/j.0513-4870.2023-0067
- VernacularTitle:藿香中的两个新乌苏烷型三萜
- Author:
Ya-ting REN
1
;
Bei LI
1
;
Jie MA
1
;
Yu-huan LI
2
;
Ying-da ZANG
1
;
Chuang-jun LI
1
;
Dong-ming ZHANG
1
Author Information
1. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
2. Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
- Publication Type:Research Article
- Keywords:
italic>Agastache rugosa (Fisch.et.Mey.) O.Kuntze;
chemical composition;
ursane triterpenoid;
anti-coxsackievirus B3 (CVB3) activities
- From:
Acta Pharmaceutica Sinica
2023;58(6):1650-1654
- CountryChina
- Language:Chinese
-
Abstract:
Two new ursane triterpenoids along with twelve known compounds were isolated from 80% ethanol extract of Agastache rugosa (Fisch. et. Mey.) O. Kuntze by using silica gel column, MCI column, ODS column and HPLC. The structures of the new compounds were identified as 2α,3α-dihydroxy-24-nor-urs-4(23),12(13)-dien-28-oic acid (1) and 2α,3α-dihydroxy-24-nor-urs-4(23),12(13),20(30) -trien-28-oic acid (2) by HR-ESI-MS, NMR and ECD spectral data, named agasursacid A and agasursacid B. In addition, compounds 3, 4, 6, 8 showed anti-coxsackievirus B3 (CVB3) activities with a IC50 as 4.77, 1.59, 11.11 and 25.87 μmol·L-1, resepectively.
