Research progress of ProTide technology and its application in the development of antiviral drugs
10.16438/j.0513-4870.2022-1210
- VernacularTitle:ProTide技术研究进展及其在抗病毒药物研究领域中的应用
- Author:
Hui-yu ZHOU
;
Mei ZHU
;
Yu-cheng WANG
- Publication Type:Research Article
- Keywords:
ProTide;
rug design;
prodrug;
phosphoramidate (or phosphonamidate);
antiviral
- From:
Acta Pharmaceutica Sinica
2023;58(6):1540-1556
- CountryChina
- Language:Chinese
-
Abstract:
ProTide technology is a kind of prodrug design strategy invented by the team of Christopher McGuigan. ProTides are aryloxyphosphoramidates (or aryloxyphosphonamidates) which contain a phosphorus atom combined with an amino acid ester and an aryloxy group. These prodrugs can efficiently cross the cell membrane and escape from the first rate-limiting step of phosphorylation, which afford effective solutions to the drawbacks of current nucleoside analogues. At present, ProTide technology has been extensively applied in the field of antiviral research. It has been successful in providing a number of approved drugs and clinical candidates, such as sofosbuvir and so much more, highlighting the promising future in drug discovery. This review summarizes the brief history and characteristics of ProTide technology, as well as its application in the exploration of antiviral drugs.
