Chiral separation methods and the applications in the study of chiral components of traditional Chinese medicines
10.16438/j.0513-4870.2022-1198
- VernacularTitle:手性分离方法及在中药手性成分研究中的应用
- Author:
Yi-fan LI
1
,
2
;
Long-chan LIU
1
;
Lin-nan LI
1
;
Zheng-tao WANG
1
,
3
,
4
;
Li YANG
1
,
2
,
3
,
4
Author Information
1. The MOE Key Laboratory of Standardization of Chinese Medicines and the SATCM Key Laboratory of New Resources and Quality Evaluation of Chinese Medicines, Shanghai Key Laboratory of Compound Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
2. Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
3. Shanghai R&
4. D Center for Standardization of Chinese Medicines, Shanghai 201203, China
- Publication Type:Research Article
- Keywords:
chiral separation;
chiral packing material;
chiral compound;
traditional Chinese medicine;
natural product
- From:
Acta Pharmaceutica Sinica
2023;58(6):1566-1576
- CountryChina
- Language:Chinese
-
Abstract:
Chirality is one of the fundamental properties of nature, and most of the important molecules in living organisms contain chiral structures. The efficacy and safety of drugs are often closely related to the chiral structure of compounds, however, there are relatively more studies on synthetic characterization, pharmacology, and toxicology of chiral small molecule chemical drugs, but relatively less studies on chiral compounds contained in natural drugs such as traditional Chinese medicines. Chiral separation, as the basis of chiral research, has a pivotal position in the study of chiral compounds. In this paper, we systematically describe the separation methods of chiral compounds from the classification of chiral splitting methods based on chromatographic and non-chromatographic methods, as well as chromatographic packing materials, chiral additives and chiral derivatization, and review the chiral compounds in natural drugs such as traditional Chinese medicines reported in the past ten years, in order to provide references for the splitting and evaluating the activity of chiral compounds, and the improvement of quality standards of traditional Chinese medicines.
