The function and drug development progress of free fatty acid receptor 1 in chronic inflammatory diseases

VernacularTitle:游离脂肪酸受体1在慢性炎症性疾病中的功能及药物研究进展
Author: Xue-feng GAO ; Cun-yu FENG ; Ya-xin FU ; Lei-lei CHEN ; Shuai-nan LIU ; Yi HUAN
Publication Type:Research Article
Keywords: free fatty acid receptor 1; chronic inflammatory disease; mechanism of action; rug development; metabolic disorder; cognitive deficit
From: Acta Pharmaceutica Sinica 2023;57(6):1505-1514
CountryChina
Language:Chinese
Abstract: As a member of G protein coupled-receptors superfamily, free fatty acid receptor 1 (FFAR1), is also known as GPR40, has been shown to regulate numerous pathophysiological processes in a variety of tissues and organs. The activated FFAR1 has a variety of biological functions. For instance, it can not only regulate metabolism of fatty acids and glucose, but also play an important role in immune inflammatory response, it may be a potential drug target for the treatment of various chronic inflammatory diseases. In this review, we focus on the recent researches of FFAR1's action in the regulation of pathophysiological processes, its molecular mechanism and new agonists development. At the same time, this review will take the discovery of series FFAR1 agonists as examples, and display the applied prospects of FFAR1.