Research progress on ferroptosis regulated by glycolysis-fatty acid metabolism in metabolic diseases
10.16438/j.0513-4870.2022-1339
- VernacularTitle:糖酵解-脂肪酸代谢失衡调控的铁死亡在代谢性疾病中的研究进展
- Author:
Xiao-man JIANG
1
;
Ran DENG
2
;
Yi WEI
1
;
Shi-lin XIA
1
;
Jing XU
1
;
Ya LI
1
;
Hong WU
1
Author Information
1. Anhui Province Key Laboratory of Research and Development of Chinese Medicine, Key Lab of Xin′an Medicine, Ministry of Education, School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, China
2. School of Integrated Traditional and Western Medicine, Anhui University of Chinese Medicine, Hefei 230012, China
- Publication Type:Research Article
- Keywords:
ferroptosis;
glycolysis;
fatty acid metabolism;
metabolic disease;
lipid peroxidation
- From:
Acta Pharmaceutica Sinica
2023;58(5):1204-1210
- CountryChina
- Language:Chinese
-
Abstract:
In metabolic diseases, the accumulation of reactive oxygen species and oxidative stress are closely associated with ferroptosis. As a key regulatory factor, the imbalance between glycolysis and fatty acid metabolism can participate in ferroptosis directly or indirectly, thereby regulating the occurrence and development of various metabolic diseases. The essence of ferroptosis is a new regulatory cell death mode, which is caused by the excessive accumulation of iron-dependent lipid peroxide. It is closely related to glycolysis and fatty acid metabolism, which plays an important role in metabolic diseases. This regulatory cell death mode is significantly distinguished from other programmed cell death modes and has unique changes in cell morphology, symbolic characteristics and mechanisms. This paper first illustrates the main mechanism of glycolysis and fatty acid metabolism imbalance in the occurrence of ferroptosis, then reviews the research progress of ferroptosis in tumor, diabetes, rheumatoid arthritis and other metabolic diseases, and finally reveals the internal connection between glycolysis-fatty acid metabolism imbalance and ferroptosis, as well as its impacts on metabolic diseases, which provide new strategies for the prevention and treatment of metabolic diseases.
